PHARMACEUTICAL COMPOSITION CONTAINING AMLODIPINE AND LOSARTAN Russian patent published in 2010 - IPC A61K31/4418 A61K31/4178 A61K9/24 A61P9/10 A61P9/12 

FIELD: medicine.

SUBSTANCE: there are offered a pharmaceutical composition for prevention or treatment of cardiovascular disturbances, containing Amlodipine or its pharmaceutically acceptable salt and Losartan or its pharmaceutically acceptable salt wherein Amlodipine or its pharmaceutically acceptable salt and Losartan or its pharmaceutically acceptable salt are physically separated from each other, and a method for preparing thereof. The method includes the following stages: a) wet granulation and drying of mixed Amlodipine or its salts and pharmaceutically acceptable excipients to prepare a portion containing Amlodipine granules; and b) mixing of the portion containing Amlodipine granules prepared at the stage a) and pre-mixed Losartan or its salt and pharmaceutically acceptable excipients.

EFFECT: improved preventive and therapeutic effects in cardiovascular disturbances, better stability, solubility, absence of hygroscopicity in making the tablets.

12 cl, 5 dwg, 1 tbl, 15 ex