BENZIMIDAZOLE DERIVATIVE, METHOD FOR OBTAINING THEREOF AND USE THEREOF IN MEDICINE Russian patent published in 2024 - IPC C07D405/14 A61K31/4545 A61P3/10 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (I) or a stereoisomer thereof:

where A is selected from a group consisting of a phenyl ring, , ,

, , and ; R¹ is selected from a group consisting of a hydrogen atom, fluorine, chlorine, bromine, cyano, difluoroethyl and trifluoroethyl; m is 0, 1 or 2; W is O; R² is selected from the group consisting of a hydrogen atom, chlorine, cyano, trifluoromethyl, methoxy and methoxymethyl; R³ is selected from the group consisting of a fluorine atom, hydroxyl, oxo (= O), methyl, fluoromethyl and methoxymethyl; q is 0 or 1; X is CH or N; Y is CH or N; R⁵ is methyl; R⁴ is oxetan-2-ylmethyl; in Z¹ is CH; Z² is CH; Z³ is CH or N; and in Z¹ is N, Z² is CH, or N, or CF, and Z³ is CH or CF, as well as to a pharmaceutical composition and use of a compound of formula (I) for preparing a medicament for treating diseases associated with GLP-1.

EFFECT: novel compounds which can be used for preparing a drug for treating GLP-1-associated diseases, especially those associated with diabetes mellitus, are obtained.

9 cl, 3 tbl, 55 ex, 1 dwg