FIELD: pharmaceutics.
SUBSTANCE: present document discloses a pharmaceutical composition containing two or more compounds, wherein each compound independently represents a phosphodiesterase inhibitor, an adenosine receptor antagonist, a calcium channel blocker, histamine H1 receptor agonist, a histamine H2 receptor agonist, histamine H3 receptor antagonist or β2-adrenoceptor agonist. Present document also discloses a method of treating, preventing or relieving cardiovascular disease in a subject, comprising administering to a subject in need thereof two or more compounds, wherein each compound is independently a phosphodiesterase inhibitor, an adenosine receptor antagonist, a calcium channel blocker, an agonist of histamine H1 receptor agonist, histamine H2 receptor antagonist, histamine H3 receptor agonist or β2-adrenoreceptor.
EFFECT: disclosed is a method of treating, preventing or relieving a cardiovascular disease.
13 cl, 6 tbl, 10 ex
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