METHOD FOR PREDICTION OF RESPONSE TO CARDIAC RESYNCHRONISING THERAPY IN PATIENTS WITH CHRONIC HEART FAILURE Russian patent published in 2020 - IPC A61B5/00 A61B8/06 G01N33/49 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to clinical cardiology, and can be used for prediction of the response to cardiac resynchronizing therapy in the patients with chronic cardiac failure. It is followed by echocardiography. Left ventricular ejection fraction is determined in echocardiography in %. Patient is additionally examined for cystatin C in ng/l, matrix metalloproteinase in ng/l, C-reactive protein in ng/l in blood. Based on the obtained data, the value of the function F is determined: F=3.231+0.344×EF-3.479×CYSTATIN-0.039×MMP9-0.638×CRB, where EF – left ventricular ejection fraction, %, CYSTATIN - level of cystatin C in ng/l, MMP9 – level of matrix metalloproteinase – 9 in ng/l, CRB – level of C-reactive protein in ng/l. Cardiac resynchronization therapy (P) response is predicted: P=1/(1+e^(-F)). If P is less than 0.696, belonging to a group of nonresponders is determined. If P is greater than or equal to 0.696, belonging to a group of responders is determined and a response to a cardiac resynchronization therapy is predicted.

EFFECT: method enables accurate, quick and simple prediction of developing a response to cardiac resynchronization therapy by a mathematical model of logistic regression based on results of echocardiographic examination and laboratory analysis using.

1 cl, 2 ex