METHOD FOR PREDICTING THE RISK OF POSTOPERATIVE THROMBOTIC COMPLICATIONS IN PATIENTS WITH HEPATIC CIRRHOSIS FOLLOWING TRANSJUGULAR INTRAHEPATIC PORTOSYSTEMIC SHUNTING Russian patent published in 2020 - IPC A61B5/00 G01N33/48 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to surgery, and concerns predicting the risk of developing postoperative thrombotic complications in patients with hepatic cirrhosis following transjugular intrahepatic portosystemic shunting (TIPS). On the second postoperative day after the surgical intervention in the TIPS volume, a laboratory examination is performed to determine IHR, prothrombin time, clot size in 30 minutes and presence of spontaneous clots. That is followed by evaluating the risk of postoperative thrombosis – Y1 classification and the risk of shunt thrombosis – Y2 by formulas: Y1=B01+(B11*X1)+(B21*X2)+(B31*X3)+(B41*X4), where B01 is model constant for group with no risk of shunt thrombosis, equal to -147.127; B11=33.088; B21=3.344; B31=0.174; B41=-13.602 are coefficients for a formula for calculating the weight of the classification of the patient's identity to the group with no predicted thrombosis in the shunt; X1 is the IHR predictor value in standard units; X2 – prothrombin time predictor value, in seconds; X3 is the predictor value clot size in 30 minutes, in mcm; X4 – predictor value presence of spontaneous clots: 0 – in the absence of spontaneous clots, 1 – in the presence of spontaneous clots; Y2=B02+B12*X1+B22*X2+B32*X3+B42*X4, where B02 is model constant for group with risk of shunt thrombosis development, equal to -201.737; B12=42.484; B22=3.966; B32=0.194; B42=-8.626 – coefficients for weight calculation formula of patient's belonging to the group with formation of thrombosis in the shunt; X1 – value of IHR predictor, in conventional units, X2 – value of prothrombin time predictor, in seconds, X3 – value of predictor clot size in 30 minutes, in mcm, X4 – value of predictor presence of spontaneous clots: 0 – in the absence of spontaneous clots, 1 – in the presence of spontaneous clots, the value Y1>Y2 predicts no risk of shunt thrombosis in the patient in the postoperative period, while Y1<Y2 – predicting a high risk of postoperative thrombosis of the shunt in the patient.

EFFECT: method enables high-accuracy prediction of a risk of developing postoperative thrombotic complications in patients with hepatic cirrhosis after performing transjugular intrahepatic portosystemic shunting (TIPS).

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