TRIALKYL CATIONIC LIPIDS AND METHODS FOR USING THEM Russian patent published in 2020 - IPC C07C217/08 C07C229/12 C07C271/20 A61K47/18 

FIELD: chemistry.

SUBSTANCE: invention relates to a lipid having the structural formula X-A-Y-Z (I), or a salt thereof, which can be used to deliver a therapeutic agent, such as a nucleic acid, into a cell. In formula (I), X is a dialkylamino group; A is C₁-C₆ alkyl; Y is selected from a group consisting of carbamate, an ester, optionally substituted with carbamate alkyl and ether; Z is a hydrophobic moiety and has formula , where R₁, R₂, and R₃ are each independently selected from a group consisting of C₈-C₁₁ alkyl, where each of R₁, R₂, and R₃ independently can be saturated or unsaturated. Invention also relates to specific lipids of formula (I), lipid particles containing said lipids, a pharmaceutical composition containing said lipid particles, methods of introducing and delivering a therapeutic agent such as nucleic acid in vivo into a cell.

EFFECT: methods of using trialkyl cationic lipids are disclosed.

20 cl, 6 tbl, 4 ex