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(19)

(11)

2 623 160

(13)

(51)

IPC

C07K14/435(2006-01-01)

C07K19/00(2006-01-01)

C12N15/11(2006-01-01)

A61K31/713(2006-01-01)

A61P1/16(2006-01-01)

(21) (22)

Application

2013117285, 2011-12-16

(24)

Start date

2011-12-16

(22)

Actual filing date

2011-12-16

(45)

Published

2017-06-22

(72)

Inventor

Rozema Devid B.Lyuis Devid L.Vejkfild Darren Kh.Kitas Erik A.Khadviger FilippVolf Dzhon A.Roel IngoMor PiterKhofmann TorstenZhan-Khoffman KerstinMyuller Khans MartinOtt GyunterBlokhin Andrej V.Benson Dzhonatan D.Karlson Dzheffri S.

(73)

Holder

Erroukhed Farmasyutikalz, Ink.

COMPOSITION OF DELIVERY SYSTEM BASED ON CONJUGATE FOR RNA-INTERFERENCE POLYNUCLEOTIDE DELIVERY TO LIVER CELL AND PROCESS FOR ITS PREPARATION Russian patent published in 2017 - IPC C07K14/435 C07K19/00 C12N15/11 A61K31/713 A61P1/16

Abstract RU 2623160 C9

FIELD: biotechnology.

SUBSTANCE: RNA-interference polynucleotide is administered in conjunction with a targeting melittin peptide modified by asialoglycoprotein (ASGPr) receptors, for delivery to a mammal liver cell.

EFFECT: functional penetration through liver cells membranes to provide RNA-interference polynucleotide movement into the cells.

20 cl, 5 dwg, 11 tbl, 18 ex

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RU 2 623 160 C9

Authors

Rozema Devid B.

Lyuis Devid L.

Vejkfild Darren Kh.

Kitas Erik A.

Khadviger Filipp

Volf Dzhon A.

Roel Ingo

Mor Piter

Khofmann Torsten

Zhan-Khoffman Kerstin

Myuller Khans Martin

Ott Gyunter

Blokhin Andrej V.

Benson Dzhonatan D.

Karlson Dzheffri S.

Dates

2017-06-22—Published

2011-12-16—Filed