FIELD: biotechnology.
SUBSTANCE: invention represents a pharmaceutical composition containing a polyribonucleotide (RNA), a sequence of which codes bone morphogenetic protein (BMP). Present invention also relates to complexes which include or form a complex with RNA of BMP, in particular with corresponding complexes for transfection, for example with complexes for lipofection, magnetofection and magnetic lymphocyte treatment. Present invention also relates to a matrix for the sustained delivery of mRNA and to use thereof in bone regeneration in vivo, ex vivo and in vitro.
EFFECT: for use in (i) treating or preventing bone disease, bone disorder or bone injury and/or (ii) inducing or increasing osteogenic differentiation, osteogenesis, ossification, bone regeneration and/or bone morphogenesis in the patient.
23 cl, 6 tbl, 14 ex, 30 dwg
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