FIELD: biotechnology.
SUBSTANCE: invention relates to and concerns eukaryotic cells suitable for recombinant production of a product of interest, where function of expression product of C12orf35 endogenous gene in said cell is inhibited, which increases its productivity, that is to increase the level of recombinant expression of polypeptide of interest. Besides, the present invention relates to technologies of recombinant production, in which such host cells are used.
EFFECT: novel eukaryotic cells and methods of producing said eukaryotic cells are proposed for recombinant expression of a product of interest.
20 cl, 20 tbl, 8 ex, 10 dwg
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