PROSTAGLANDIN FALPHA DERIVATIVES FOR REDUCING INTRAOCULAR PRESSURE Russian patent published in 2020 - IPC C07C405/00 C07D207/08 A61K31/5575 A61P27/00 

FIELD: chemistry; medicine.

SUBSTANCE: invention refers to medical chemistry, specifically to a compound of the following general formula or pharmaceutically acceptable salts thereof. In said general formula R¹=H, , where n=1–4, or R¹=H, , where R³=CHMe₂, HNCH₂CH₂ONO₂, OCH₂CH₂ONO₂, OCH(CH₂ONO₂)₂, or R¹=H, , where R⁴=H, CHMe₂; R⁵=H, OH; R⁶=H, OH, ONO₂, CH₂OH, CH₂ONO₂, or R¹=H, R²=CH₂CH₂OC(O)NHCH₂CH₂ONO₂, or R¹=H, R²=CH₂CH₂OC(O)OCH(CH₂ONO₂)₂, or , where n=1, 2. .

EFFECT: compounds according to the present invention are capable to reduce intraocular pressure, at that have low cytotoxicity and are capable to stimulate formation of endogenous nitrogen oxide in cells.

3 cl, 3 tbl, 1 dwg, 7 ex