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2 732 297

(13)

(51)

IPC

C07C39/06(2006-01-01)

C07C233/30(2006-01-01)

C07D209/02(2006-01-01)

C07D209/26(2006-01-01)

A61K31/403(2006-01-01)

A61K31/405(2006-01-01)

A61K31/165(2006-01-01)

A61P29/00(2006-01-01)

(21) (22)

Application

2018140051, 2018-11-14

(24)

Start date

2018-11-14

(22)

Actual filing date

2018-11-14

(45)

Published

2020-09-15

(72)

Inventor

Bezuglov Vladimir VilenovichSerkov Igor ViktorovichLyubimov Igor IvanovichGretskaya Natalya MikhajlovnaAkimov Mikhail GennadevichTeterin Igor Yurevich

(73)

Holder

Obshchestvo S Ogranichennoj Otvetstvennostyu Biofarm"

DERIVATIVES OF NON-STEROID ANTI-INFLAMMATORY AGENTS Russian patent published in 2020 - IPC C07C39/06 C07C233/30 C07D209/02 C07D209/26 A61K31/403 A61K31/405 A61K31/165 A61P29/00

Abstract RU 2732297 C2

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to a compound of general formula (I) applicable in medicine:

where R is a non-steroidal anti-inflammatory agent residue containing a carboxyl group, attached by an amide bond and representing diclofenac, ibuprofen, naproxen, ketorolac, aceclofenac, indometacin, ketoprofen or sulindac, and X is CH₂, (CH₂)₃CONHCH₂ or CH₂CH₂O(CO)NHCH₂, wherein when X is CH₂, R cannot be a residue of ibuprofen, ketoprofen or sulindac.

EFFECT: invention discloses novel compounds which are effective for use as an agent possessing anti-inflammatory, cytotoxic and/or neuroprotective activity.

2 cl, 4 tbl, 10 ex

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RU 2 732 297 C2

Authors

Bezuglov Vladimir Vilenovich

Serkov Igor Viktorovich

Lyubimov Igor Ivanovich

Gretskaya Natalya Mikhajlovna

Akimov Mikhail Gennadevich

Teterin Igor Yurevich

Dates

2020-09-15—Published

2018-11-14—Filed