LOW-MOLECULAR DERIVATIVES OF CARBOXAMIDE HALOGENATED PORPHYRINS, SPECIFICALLY CHLORINES AND BACTERIOCHLORINS, AND USE THEREOF Russian patent published in 2020 - IPC C07D487/22 A61K31/409 A61K41/00 A61P35/00 A61P31/00 

FIELD: pharmaceuticals.

SUBSTANCE: present invention relates to carboxamide halogenated porphyrin derivatives, in particular bacteriochlorine or chlorine, of formula (I):

formula (I).

In formula (I): is a carbon-carbon single bond or a carbon-carbon double bond, provided that at least one is a carbon-carbon single bond; Y₁, Y₂ are each independently selected from hydrogen or halogenated alkyl, or halogenated cycloalkyl with 6 or less carbon atoms, or halogenated phenyl, wherein halogens are independently selected from F, Cl and Br, with the proviso that at least one of Y₁, Y₂ is not hydrogen; R₁ is H'; R' and R" are independently selected from hydrogen, alkyl with 6 or less carbon atoms, cyclopropyl, cyclobutyl or cyclopentyl. What is also presented is a pharmaceutical composition and a kit containing it.

EFFECT: disclosed compounds are used as a photosensitizer for PDT of hyperproliferative disorders and/or for photoinactivation of bacteria or viruses, or fungi, meet all criteria of ideal photosensitizer and effectively overcome biological barriers.

24 cl, 8 dwg, 2 tbl, 7 ex