GENETIC ENGINEERING STRUCTURE FOR STIMULATING POST-TRAUMATIC REGENERATION OF PERIPHERAL NERVES Russian patent published in 2020 - IPC A61K48/00 A61K9/00 A61P21/00 C12N15/86 

FIELD: medicine.

SUBSTANCE: proposed group of inventions refers to medicine, particularly to biotechnology and pharmaceutics. Disclosed is a genetically engineered structure for stimulating post-traumatic regeneration of peripheral nerves, representing a vector with built-in hBDNF and huPA cDNA sequences and a regulatory sequence comprising an enhancer embedded in a cytomegaloviral promoter sequence, artificial intron and site of internal planting of hepatitis C virus ribosome. Application of the above genetic engineering structure as a gene therapy agent for peripheral nerves injuries is proposed. What is also presented is a dosage form containing the above genetic engineering structure as an active ingredient, and a method for stimulating local expression of hBDNF and huPA in perineural tissues in the area of trauma involving administering a dosage form.

EFFECT: proposed group of inventions provides coordinated localized expression of two proteins with achieving optimal ratio of production of recombinant hBDNF and production of huPA.

6 cl, 12 dwg, 9 tbl, 7 ex