MEDICINAL AGENT FOR TREATING HEPATIC FIBROSIS, METHOD FOR PRODUCTION THEREOF AND METHOD OF TREATING HEPATIC FIBROSIS Russian patent published in 2017 - IPC A61K38/18 A61K38/49 A61K48/00 A61P1/16 C12N15/63 

FIELD: biochemistry.

SUBSTANCE: invention relates to biochemistry, biotechnology and genetic engineering, in particular, to a drug for treating hepatic fibrosis based on a mixture of two non-viral plasmid structures. First non-viral plasmid structure is pC4W-HGFopt and comprises a gene, which codes human hepatocyte growth factor. Second is a pVax1-UPAopt and contains a gene coding human urokinase. In said drug plasmid structures are contained in following concentrations: pC4W-HGFopt – from 0.5 to 0.7 mg/ml; pVax1-UPAopt – from 0.3 to 0.5 mg/ml, wherein total concentration of DNA is 1±0.01 mg/ml. Present invention discloses a method of producing said drug and method of treating hepatic fibrosis using said drug in a pharmaceutically acceptable amount.

EFFECT: present invention enables to produce a drug for treating hepatic fibrosis, having higher efficiency, which is safe and easy to produce.

12 cl, 28 dwg, 4 tbl, 9 ex