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IPC

A61K48/00(2006-01-01)

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Application

2011143050/15, 2011-10-25

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Start date

2011-10-25

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Actual filing date

2011-10-25

(45)

Published

2013-07-10

(72)

Inventor

Parfenova Elena ViktorovnaTkachuk Vsevolod Arsen'EvichRubina Ksenija AndreevnaKalinina Natal'Ja IgorevnaKaragjaur Maksim NikolaevichStambol'Skij Dmitrij ViktorovichSemina Ekaterina VladimirovnaLopatina Tat'Jana VladimirovnaSysoeva Veronika Jur'Evna

(73)

Holder

Federal'Noe Gosudarstvennoe Bjudzhetnoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennyj Universitet Imeni M.V. Lomonosova"

METHOD FOR STIMULATING RECOVERED PERIPHERAL TISSUE INNERVATION Russian patent published in 2013 - IPC A61K48/00

Abstract RU 2486918 C1

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to biotechnology and gene therapy, and may be used in regenerative medicine, traumatology, transplantology and neurobiology. A method for stimulating the recovered peripheral tissue innervation following an injury comprises administering a therapeutically effective amount of a plasmid vector containing the BDNF-coding nucleotide sequence SEQ ID NO:1, or a plasmid vector containing the human wild-type uPA (NM002658) coding nucleotide sequence, or combinations thereof, or combinations of the plasmid vector containing the BDNF-coding nucleotide sequence SEQ ID NO:1 and a plasmid vector containing a stromal cell factor SDF-1 coding optimised nucleotide sequence SEQ ID NO: 2.

EFFECT: method enables a faster posttraumatic recovery of the peripheral nerve structure and patency due to a local increase of neurotrophic factor production.

3 cl, 9 dwg, 4 ex

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RU 2 486 918 C1

Authors

Parfenova Elena Viktorovna

Tkachuk Vsevolod Arsen'Evich

Rubina Ksenija Andreevna

Kalinina Natal'Ja Igorevna

Karagjaur Maksim Nikolaevich

Stambol'Skij Dmitrij Viktorovich

Semina Ekaterina Vladimirovna

Lopatina Tat'Jana Vladimirovna

Sysoeva Veronika Jur'Evna

Dates

2013-07-10—Published

2011-10-25—Filed