GLUCOSE-RESPONSIVE INSULIN DELIVERY SYSTEM USING HYPOXIA-SENSITIVE NANOCOMPOSITES Russian patent published in 2020 - IPC A61K38/28 A61K38/44 A61K47/30 A61K47/34 A61K47/36 A61K9/50 A61K9/51 A61K9/70 A61P3/10 

FIELD: chemistry.

SUBSTANCE: invention relates to a glucose-responsive delivery composition for treating diabetes in a subject in need thereof. Composition contains: amphiphilic polymer material, wherein amphiphilic polymer material contains hydrophilic polymer conjugated with hydrophobic group hypoxia-sensitive, wherein the hypoxia-sensitive hydrophobic group contains a hypoxia-sensitive fragment which can be reduced in the presence of a hypoxic environment to form a hydrophilic fragment, wherein the hydrophilic polymer is selected from a group consisting of a polyamino acid, a synthetic block copolymer and a polysaccharide, and the hypoxia-sensitive hydrophobic group is nitroimidazole; diabetes treatment agent; and a glucose-oxidising agent. Invention also discloses a nanoparticle, a vesicle, a micro needle-like matrix, a closed-insulin delivery system, a method of delivering an agent for treating diabetes, a method of producing a micro needle-shaped matrix.

EFFECT: invention provides fast delivery of insulin to a subject in response to changes in blood glucose and virtually painless.

40 cl, 27 dwg, 6 ex