FIELD: medicine.
SUBSTANCE: device contains a microneedle and multiple nanostructures produced on its surface. They are arranged in a given pattern that provides nanotopography, which, by interacting with surrounding tissues, facilitates high-viscosity composition transportation through the dermal barrier. The device also comprises a fluidly communicating composition comprising a bioactive agent and having a viscosity greater than about 5 centipoise. A method for bioactive agent delivery includes penetration through the stratum corneum with a micro-needule of the claimed device and provision of conditions for composition transportation through the microneedle at a rate above about 0.4 mg/h/cm2 depending on the microneedle surface area.
EFFECT: high-viscosity therapeutic composition delivery through the dermal barrier.
12 cl, 3 ex, 3 tbl, 34 dwg
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