PHARMACEUTICAL AGENTS, COMPOSITIONS, AND METHODS RELATED THERETO Russian patent published in 2022 - IPC A61K31/7076 C07H19/167 A61P3/10 

FIELD: pharmaceuticals.

SUBSTANCE: present group of inventions relates to the field of chemistry, pharmaceuticals, and medicine, namely, to selenium-containing compounds useful for treating disorders associated with type II diabetes, represented by the general formula 2, or a pharmaceutically acceptable salt or ester thereof, wherein R⁸ represents H; X represents H; each R₅' independently represents H or halogen; and each R independently represents_1-6alkyl, each whereof may be independently optionally substituted 1 to 3 times with halogen. Also described are pharmaceutical compositions for modulating glucose metabolism and, on the basis of the above compounds, a method for treating disorders associated with insulin, also described are a method for inhibiting production of glucose, a method for reducing the level of HbA1c in the serum, a method for reducing the level of HbA1c in the serum, a method for increasing glucose tolerance, a method for enhancing phosphorylation of Pdk1, Akt, AS160, and Foxo1 in the liver and/or skeletal muscles, etc.

EFFECT: provided excellent activity, reduction in the glucose production in the liver and/or improved glucose tolerance in insulin-resistant patients with diabetes.

36 cl, 28 dwg, 1 tbl, 11 ex