SUSTAINED-RELEASE DELIVERY COMPOSITION AND A METHOD FOR STABILIZING PROTEINS IN THE MANUFACTURING PROCESS Russian patent published in 2020 - IPC A61K47/18 A61K47/40 A61K47/56 A61K9/64 A61K38/02 A61P27/02 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: group of inventions relates to preparations for continuous delivery of active substances. Disclosed is a composition for treating an eye pathology, comprising particles, wherein the particles contain an anticalin, a biodegradable polymer and one or more adjuvant and are capable of sustained continuous release of anticalin for at least two months; biodegradable polymer contains a poly(d,l-lactide-co-glycolide) copolymer with 75 mol % polylactic acid and 25 mol % polyglycolic acid and has an intrinsic viscosity in range of 0.50 dl/g to 0.70 dl/g; one or more adjuvants contains sulphobutylether-beta-cyclodextrin, trehalose, arginine or a combination thereof; wherein said excipients are present in amount of 5 to 15 % by weight based on the total weight of the composition, and the anticalin is present in amount of 5 to 50 % by weight. Also disclosed is use of said composition for treating eye pathologies and an aqueous preparation containing anticalin and one or more of said excipients.

EFFECT: group of inventions provides stabilization of highly concentrated solution of anticalin by using said excipients.

4 cl, 9 dwg, 4 tbl, 8 ex