HISTONE DEACETYLASE INHIBITORS Russian patent published in 2020 - IPC C07D223/08 C07D223/12 C07D451/04 C07D451/06 C07D205/04 C07D207/12 C07D207/14 C07D211/46 C07D211/58 A61K31/397 A61K31/40 A61K31/44 A61K31/4409 A61K31/46 A61K31/55 A61P25/00 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to a compound of formula (I), or a pharmaceutically acceptable salt thereof

,

where ring A is 4–7 membered heterocycloalkyl ring, containing one ring nitrogen atom, or 7–9-member bicyclic heterocycloalkyl ring containing one ring nitrogen atom; Z is O, NR³, S or SO₂; R¹ is H, C_1-6alkyl, C_1-6hydroxyalkyl, C(O)C_1-6alkyl, C_0-3alkylene-C_3-10cycloalkyl or C_0-3alkylene-C_2-5heterocycloalkyl containing 1 or 2 heteroatoms selected from O, S, N and N (C_1-4alkyl); R² denotes H, F, Cl or CH₃; R³ is H, C_1-6alkyl, C_1-6haloalkyl, C_0-3alkylene-C_3-7cycloalkyl, C(O)C_1-6alkyl or C(O)C_0-3alkylene-C_3-7cycloalkyl; and R⁴ is H or C_1-3alkyl, as well as a pharmaceutical composition, a method of treating and methods of inhibiting histone deacetylase ("HDAC") enzymes (e.g., HDAC1, HDAC2 and HDAC3) using compounds of formula (1).

EFFECT: disclosed are histone deacetylase inhibitors.

98 cl, 2 tbl