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2 515 972

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(51)

IPC

C07D471/14(2006-01-01)

A61K31/437(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2010154105/04, 2009-06-10

(24)

Start date

2009-06-10

(22)

Actual filing date

2009-06-10

(45)

Published

2014-05-20

(72)

Inventor

Dajk Khejzel DzhoanEhllvud Charl'ZGansia EhmanuehlaGazzard L'Juis Dzh.Gudehjkr Sajmon Charl'ZKintz Samuehl' S.Lissikatos Dzhozef P.Makleod KalumUill'Jams Karen

(73)

Holder

Dzhenentek, Ink.

DIAZACARBAZOLES AND METHODS OF APPLICATION Russian patent published in 2014 - IPC C07D471/14 A61K31/437 A61P35/00

Abstract RU 2515972 C2

FIELD: chemistry.

SUBSTANCE: invention relates to 1.7-diazacarbazole compounds of formula (I) or to its solvates, hydrates or salts , where X, Y, Z, R³, R⁵ and R⁶ are such as given in i.1 of the invention formula. In addition, invention relates to pharmaceutical composition, containing formula (I) compounds, which possesses inhibiting activity with respect to kinase of control point 1 (chk1).

EFFECT: novel compounds, which can be useful as kinase inhibitors and therefore are useful as anticancer therapeutic medications, are obtained and described.

26 cl, 403 ex, 16 tbl

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RU 2 515 972 C2

Authors

Dajk Khejzel Dzhoan

Ehllvud Charl'Z

Gansia Ehmanuehla

Gazzard L'Juis Dzh.

Gudehjkr Sajmon Charl'Z

Kintz Samuehl' S.

Lissikatos Dzhozef P.

Makleod Kalum

Uill'Jams Karen

Dates

2014-05-20—Published

2009-06-10—Filed