FIELD: medicine; pharmaceuticals.
SUBSTANCE: invention relates to a novel maleate of a compound of formula I, in which the molar ratio of the compound of formula I to maleic acid is 1:1. Formula I is a compound
EFFECT: compound has properties of tumor inhibitor mediated by EGFR kinases, HER2 kinases or mutant forms of EGFR kinases L858R/T790M, and can be used in treating tumor, mediated by activity of said kinases, for example, when tumor is non-small-cell lung cancer or malignant tumor of mammary gland.
6 cl, 5 ex, 2 tbl
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Year |
Author |
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2010 |
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2011 |
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|
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2018 |
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2014 |
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|
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2012 |
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2015 |
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