QUINAZOLINE INHIBITORS OF ACTIVATING MUTANT FORMS OF EPIDERMAL GROWTH FACTOR RECEPTOR Russian patent published in 2018 - IPC C07D403/12 A61K31/517 A61K31/495 A61P35/00 

Abstract RU 2656597 C2

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry, specifically a heterocyclic compound of formula (I) or a pharmaceutically acceptable salt thereof. Invention also relates to a pharmaceutical composition based on a compound of formula (I) or a pharmaceutically acceptable salt thereof, use thereof and a method of treating cancer. .

EFFECT: technical result: obtaining a novel compound of formula (I) and pharmaceutically acceptable salts thereof, having inhibitory activity with respect to activating mutated forms of EGFR and useful in the treatment of cancer.

16 cl, 10 tbl, 12 dwg, 7 ex

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RU 2 656 597 C2

Authors

Li David Yunzhi

Wang Jiabing

Yang Zhenfan

Zeng Qingbei

Zhang Xiaolin

Dates

2018-06-06Published

2014-03-05Filed