BISPECIFIC MOLECULES, IMMUNOREACTIVE WITH IMMUNE EFFECTOR CELLS EXPRESSING AN ACTIVATING RECEPTOR Russian patent published in 2020 - IPC C07K16/08 C07K16/10 C07K16/28 A61K39/00 A61K39/395 A61P31/12 

Abstract RU 2721707 C2

FIELD: biochemistry.

SUBSTANCE: invention relates to a bispecific diabody molecule specifically binding to an immune effector cell CD3 epitope and an epitope of an antigen expressed by an HIV-infected cell, as well as to a bispecific diabody molecule specifically binding to an immune cell effector cell epitope CD16 and an epitope of an antigen expressed by an HIV-infected cell. Also disclosed is a pharmaceutical composition containing said diabody. Invention also relates to use of said bispecific diabody molecule for treating latent, persistent and inactive HIV infection.

EFFECT: invention enables effective treatment of HIV infection.

24 cl, 7 dwg, 1 tbl, 8 ex

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RU 2 721 707 C2

Authors

Kenig, Skott

Dzhonson, Lesli S.

Lam, Chia-In Kao

Lyu, Litsin

Nordstrom, Dzheffri Li

Khejns, Barton F.

Ferrari, Gvido

Dates

2020-05-21Published

2014-03-13Filed