FIELD: biochemistry; immunology.
SUBSTANCE: present invention relates to biochemistry and immunology, in particular to a molecule of a tri-specific antibody containing a diabody unit built in a polypeptide chain containing at least six variable domains connected one after another. In some cases, two single-stranded Fv-fragments are connected distally to the diabody unit to form two additional antigen-binding sites. An antigen-binding molecule may be monomer of single polypeptide or multimeric polypeptide.
EFFECT: invention can be used for target impact on two different tumor antigens, wherein the third specificity activates a cytotoxic effect of effector cells, or binding of two effector cells and one tumor antigen; invention can be used in different ways for changing targets of a cytotoxic potential of effector cells of the immune system for destruction of tumor cells or infectious agents.
17 cl, 13 dwg, 1 tbl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| CD3-BINDING DOMAIN | 2015 |
|
RU2742691C2 |
| ADAM9-BINDING MOLECULES AND THEIR APPLICATION METHODS | 2017 |
|
RU2783619C2 |
| VARIANT CD3 BINDING DOMAINS AND THEIR USE IN COMBINATION THERAPY FOR TREATMENT OF DISEASES | 2019 |
|
RU2810222C2 |
| TRIFUNCTIONAL ANTIGEN-BINDING MOLECULE | 2015 |
|
RU2753882C2 |
| IL-12 COMPOSITIONS AIMED AT EDB | 2019 |
|
RU2758143C1 |
| BISPECIFIC ANTIGEN-BINDING PROTEIN EGFR/CD16 | 2019 |
|
RU2792240C2 |
| BISPECIFIC MOLECULES, IMMUNOREACTIVE WITH IMMUNE EFFECTOR CELLS EXPRESSING AN ACTIVATING RECEPTOR | 2014 |
|
RU2721707C2 |
| CD3-SPECIFIC BINDING MOLECULES | 2020 |
|
RU2826453C2 |
| ANTIBODIES AGAINST SIGNAL-REGULATORY ALPHA PROTEIN AND THEIR APPLICATION METHODS | 2017 |
|
RU2771964C2 |
| ANTIBODIES BINDING TO CD3 | 2019 |
|
RU2810924C2 |
