FIELD: medicine.
SUBSTANCE: invention refers to medicine, namely to experimental medicine, oncology, oncogynecology, and can be used to simulate a procarcinogenic action of fulvestrant on ovary tissue in female descendants of laboratory mice. That is ensured by intramuscularly injecting fulvestrant 100 mcg/kg of mice in form of 0.4 ml of 0.0005 % oily solution to pregnant laboratory mice on 11th day of the prenatal period.
EFFECT: method provides a model of morphological and immunohistochemical changes caused by a procarcinogenic action of a high hormone level on female ovary by introducing the effective sub-toxic dose of fulvestrant in the critical day of organ anlage, which does not cause irreversible changes in the ovaries.
1 cl, 8 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR MODELING PRO-CARCINOGENIC EFFECT OF SYNOESTROL ON THE OVARIES OF THE FEMALE OFFSPRING OF LABORATORY MICE | 2018 |
|
RU2676437C1 |
| METHOD OF DIAGNOSTICS OF NON-TUMOUROUS LESIONS OF OVARIES AT LATE TERMS OF PREGNANCY | 2009 |
|
RU2410695C1 |
| AGENT FOR TREATING FEMALE INFERTILITY AND INFERTILITY OF FEMALE ANIMALS | 2017 |
|
RU2740922C2 |
| METHOD FOR CONTROL OF SEXUAL ACTIVITY OF MAMMALS | 0 |
|
SU1837888A3 |
| PREPARATION FOR FOLLICULOGENESIS STIMULATION AND METHOD FOR ITS APPLICATION | 2016 |
|
RU2629871C1 |
| DIAGNOSTIC TECHNIQUE FOR REPRODUCTIVE OVARIAN POTENCY | 2008 |
|
RU2367949C1 |
| GENETIC ENGINEERING STRUCTURE FOR STIMULATING POST-TRAUMATIC REGENERATION OF PERIPHERAL NERVES | 2019 |
|
RU2719013C1 |
| METHOD OF MODELLING AUTOIMMUNE OOPHORITIS | 2010 |
|
RU2439712C1 |
| PROTEIN-PEPTIDE COMPLEX INCREASING THE VIABILITY OF FOLLICULES IN MAMMAL OVARIANS | 2017 |
|
RU2660587C1 |
| PHARMACEUTICAL COMPOSITION ELICITING ANALGETIC EFFECT, IMPROVING BLOOD SUPPLY, STIMULATING REGENERATION OF NERVOUS TISSUE AND ANTI-ALLERGIC EFFECT | 2003 |
|
RU2225707C1 |
