FIELD: biotechnology.
SUBSTANCE: described is an effective liquid stable combination vaccine, promoting cattle protection against a clinical disease that occurs as a result of infection, caused by cattle viral diarrhea virus (BVDV), infectious bovine rhinotracheitis virus (IBR), parainfluenza type 3 virus (PI3), bovine respiratory syncytial virus (BRSV) and/or bovine respiratory coronavirus (BRCV), wherein said stable liquid combined vaccine comprises live attenuated BVDV, live attenuated IBR, live attenuated PI3, live attenuated BRSV and live attenuated BRCV together with 10–30 % (weight/volume) of sorbitol, and amount of amino acid selected from a group, consisting of 0.17–0.46 mole of arginine or combined total 0.2–0.6 mole of arginine and glutamic acid; and where liquid stable combined vaccine has pH from 6.0 to 8.0. Present invention also discloses production of such vaccines and animal protection methods by administering said vaccines. In addition, described is an effective liquid stable vaccine, promoting cattle protection against clinical disease, which results from an infection caused by BVDV, wherein said liquid stable vaccine contains live attenuated BVDV together with 10–30 % (weight/volume) of sorbitol and amount of amino acid selected from a group, consisting of 0.17–0.46 mole of arginine or combined total 0.2–0.6 mole of arginine and glutamic acid; and where liquid stable vaccine has pH from 6.0 to 8.0. Present invention also discloses production of such vaccines and animal protection methods by administering said vaccines.
EFFECT: invention extends the range of products for treating and protecting animals.
16 cl, 2 tbl, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| LIQUID STABLE VACCINES CONTAINING A BOVINE VIRUS | 2014 |
|
RU2759880C2 |
| BOVINE VIRAL DIARRHOEA VIRUS TYPE 1B VACCINE COMPOSITIONS AND METHODS FOR PRODUCTION AND USE THEREOF | 2011 |
|
RU2595873C2 |
| DRY VACCINE COMPOSITIONS STABLE AT ROOM TEMPERATURE | 2014 |
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RU2826263C2 |
| VACCINES, STABLE AT ROOM TEMPERATURE | 2014 |
|
RU2740920C2 |
| METHOD OF DETECTING PATHOGENS OF RESPIRATORY INFECTIONS IN CATTLE: BPIV, BRSV, BHV-4, BCoV, BVDV-1, BVDV-2, BVDV-3 BASED ON MULTIPLEX POLYMERASE CHAIN REACTION (PCR) | 2022 |
|
RU2798286C1 |
| METHOD OF BACTERINATION AGAINST INFECTION OF SPERMARIES BVDV | 2005 |
|
RU2335298C2 |
| VACCINE FORMULA AGAINST BOVINE RESPIRATORY PATHOLOGIES | 2002 |
|
RU2305560C2 |
| ENHANCED IMMUNE RESPONSE IN BOVINE SPECIES | 2011 |
|
RU2606855C2 |
| SWINE VIRUS VACCINES STABLE IN LIQUID FORM | 2015 |
|
RU2695523C2 |
| LIQUID STABLE VIRAL VACCINES | 2013 |
|
RU2641970C2 |
