SERINE-THREONINE PROTEIN KINASE AND PARP MODULATORS Russian patent published in 2019 - IPC C07D471/04 A61K31/4738 A61P35/00 

FIELD: organic chemistry.

SUBSTANCE: invention relates to organic chemistry, namely, to a heterocyclic compound of the formula XV or its pharmaceutically acceptable sodium salt, where Z⁵ represents N or CH; R⁸ represents H; (C1-C3)alkyl, optionally substituted with OH; oxadiazole, optionally substituted with (C1-C3)alkyl; OR; NR₂; SR; SO₂R; NRCOR; CN; COOR; CONR₂ or ; every R⁹ is, independently, (C1-C3)alkyl, optionally substituted with up to three halogens, (C2-C3)alkynyl, halogen, OR or CN; where each R represents, independently, H or an optionally substituted group selected from (C1-C3)alkyl, cyclopropyl, piperidinyl, C2-alkynyl, C6-aryl, pyrazolyl, (C6-aryl)(C1-C3alkyl)-, (pyridyl)(C1-C4alkyl) or N(C1-C3alkyl)₂; p is 0, 1 or 2; and where optional substituents are selected from: (C1-C3)alkyl, halogen, OH, -O(C1-C3alkyl), COOH or CONH₂. Invention also relates to specific compounds, method of inhibiting cell proliferation, method of treating a condition associated with aberrant cell proliferation, method of modulating serine-threonine protein kinase activity, pharmaceutical activity based on these compounds. XV.

EFFECT: new heterocyclic compounds have been obtained that are useful in the treatment of cancer.

61 cl, 11 ex, 28 tbl