FIELD: medical virology.
SUBSTANCE: vaccine strain A/17/Slovenia/2015/1121 (H1N1)pdm09 is a reassortant produced by crossing epidemic virus A/Slovenia/2903/2015 (H1N1)pdm09 with a cold-adapted temperature-sensitive virus A/Leningrad/134/17/57 (H2N2) – an attenuation donor, which is harmless for humans. Strain A/17/Slovenia/2015/1121 (H1N1)pdm09 actively propagates in developing chick embryos at optimal temperature of 32 °C, characterized by temperature sensitivity, cold tolerance and harmlessness for laboratory animals. Reassortant has inherited genes coding surface antigens of haemagglutinin virus (HA) and neuraminidase (NA), from an epidemic parental virus and other six genes coding internal and non-structural proteins, from an attenuation donor.
EFFECT: strain can be used in practical health care for preventing the incidence of influenza in adults and children.
1 cl, 5 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| VACCINE STRAIN OF INFLUENZA A/17/NEW YORK/15/5364 (H1N1) PDM09 FOR PRODUCTION OF LIVE INFLUENZA INTRANASAL VACCINE FOR ADULTS AND CHILDREN | 2017 |
|
RU2653388C1 |
| VACCINE STRAIN OF INFLUENZA VIRUS A/17/BRISBANE/2018/8175 (H1N1) PDM09 FOR PRODUCTION OF LIVE INFLUENZA INTRANASAL VACCINE FOR ADULTS AND CHILDREN | 2019 |
|
RU2735291C1 |
| VACCINE INFLUENZA VIRUS A/17/SOUTH AFRICA/2013/01 (H1N1)PDM09 FOR PRODUCTION OF LIVE INTRANASAL INFLUENZA VACCINE FOR ADULTS AND CHILDREN | 2016 |
|
RU2627188C1 |
| REASSORTANT STRAIN OF INFLUENZA VIRUS A/17/GUANGDONG-MAONAN/2019/211 (H1N1)PDM09 FOR PRODUCTION OF LIVE INTRANASAL INFLUENZA VACCINE FOR ADULTS AND CHILDREN | 2022 |
|
RU2793387C1 |
| VACCINE INFLUENZA VIRUS STRAIN A/17/Bolivia/2013/6585 (H1N1)pdm09 FOR PREPARING LIVE INFLUENZA INTRANASAL VACCINE FOR ADULTS AND CHILDREN | 2015 |
|
RU2605314C1 |
| REASSORTANT STRAIN OF INFLUENZA A/17/IOWA/2018/5388 (H1N1)PDM09 VIRUS FOR PRODUCTION OF LIVE INFLUENZA INTRANASAL VACCINE FOR ADULTS AND CHILDREN | 2023 |
|
RU2825671C1 |
| REASSORTANT STRAIN OF INFLUENZA VIRUS A/17/VICTORIA/2019/276 (H1N1) PDM09 FOR THE PRODUCTION OF LIVE INTRANASAL INFLUENZA VACCINE FOR ADULTS AND CHILDREN | 2022 |
|
RU2783878C1 |
| REASSORTANT STRAIN OF INFLUENZA A/17/DARWIN/2018/154 (H1N1)PDM09 VIRUS FOR PRODUCTION OF LIVE INFLUENZA INTRANASAL VACCINE FOR ADULTS AND CHILDREN | 2023 |
|
RU2825670C1 |
| STRAIN OF INFLUENZA VIRUS A/17/INDIANA/11/72 (H3N2v) FOR PRODUCTION OF LIQUID INFLUENZA INTRANASAL VACCINE FOR ADULTS AND FOR CHILDREN | 2013 |
|
RU2545706C1 |
| VACCINE STRAIN OF INFLUENZA VIRUS A/17/BRISBANE/2017/7178 (H3N2) FOR PRODUCTION OF LIVE INFLUENZA INTRANASAL VACCINE FOR ADULTS AND CHILDREN | 2019 |
|
RU2711101C1 |
