FIELD: medical virology.
SUBSTANCE: invention can be used in practical public healthcare for the prevention of influenza among adults and children using a live intranasal influenza vaccine from influenza virus strain A/17/Guangdong-Maonan/2019/211 (H1N1)pdm09. Vaccine strain A/17/Guangdong-Maonan/2019/211 (H1N1)pdm09-reassortant obtained by crossing epidemic virus A/Guangdong-Maonan/SWL1536/2019 (H1N1)pdm09 with cold-adapted temperature-sensitive virus A/Leningrad/134/17/ 57 (H2N2) — an attenuation donor, harmless to human. Strain A/17/Guangdong-Maonan/2019/211 (H1N1)pdm09 actively reproduces in developing chicken embryos at an optimum temperature of 32°C, is characterized by temperature sensitivity, cold adaptation and harmlessness to laboratory animals.
EFFECT: obtaining of the reassortant that inherited the genes encoding the surface antigens of the virus, hemagglutinin (HA) and neuraminidase (NA), from the epidemic parental virus and the remaining six genes encoding internal and non-structural proteins from the attenuation donor.
1 cl, 1 dwg, 5 tbl
| Title | Year | Author | Number |
|---|---|---|---|
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|
RU2825671C1 |
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| VACCINE STRAIN OF INFLUENZA VIRUS A/17/SLOVENIA/2015/1121 (H1N1)PDM09 FOR PRODUCTION OF LIVE INFLUENZA INTRANASAL VACCINE FOR ADULTS AND CHILDREN | 2019 |
|
RU2724706C1 |
| VACCINE INFLUENZA VIRUS STRAIN A/17/Bolivia/2013/6585 (H1N1)pdm09 FOR PREPARING LIVE INFLUENZA INTRANASAL VACCINE FOR ADULTS AND CHILDREN | 2015 |
|
RU2605314C1 |
| VACCINE STRAIN OF INFLUENZA VIRUS A/17/BRISBANE/2018/8175 (H1N1) PDM09 FOR PRODUCTION OF LIVE INFLUENZA INTRANASAL VACCINE FOR ADULTS AND CHILDREN | 2019 |
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| VACCINE STRAIN OF INFLUENZA A/17/NEW YORK/15/5364 (H1N1) PDM09 FOR PRODUCTION OF LIVE INFLUENZA INTRANASAL VACCINE FOR ADULTS AND CHILDREN | 2017 |
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| STRAIN OF INFLUENZA VIRUS A/17/INDIANA/11/72 (H3N2v) FOR PRODUCTION OF LIQUID INFLUENZA INTRANASAL VACCINE FOR ADULTS AND FOR CHILDREN | 2013 |
|
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| VACCINE STRAIN OF INFLUENZA A/17/KANSAS/2017/631 (H3N2) VIRUS FOR PRODUCTION OF LIVE INFLUENZA INTRANASAL VACCINE FOR ADULTS AND CHILDREN | 2019 |
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RU2732610C1 |
