NEW BICYCLIC COMPOUNDS AS DOUBLE INHIBITORS OF AUTOTAXIN (ATX)/CARBONIC ANHYDRASE (CA) Russian patent published in 2020 - IPC C07D487/04 A61K31/407 A61P27/02 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to a compound of formula (I)

,

where R¹ is substituted phenyl-C_1-6 alkyl, substituted phenoxy-C_1-6 alkyl, substituted phenyl-C_2-6 alkenyl, substituted pyridinyl or substituted pyridinyl-C_1-6 alkyl, where substituted phenyl-C_1-6 alkyl, substituted phenoxy-C_1-6 alkyl, substituted phenyl-C_2-6 alkenyl, substituted pyridinyl and substituted pyridinyl-C_1-6 alkyl are substituted with groups R³, R⁴ and R⁵, Y is -OC(O)- or -C(O)-, W is -C(O)-, R² is substituted phenyl or substituted pyridinyl, where substituted phenyl and substituted pyridinyl are substituted groups R⁶, R⁷ and R⁸, R³ is halogen-C_1-6 alkoxy, C_1-6 alkylcarbonylamino or tetrahydropyranyl-C_1-6 alkoxy, R⁴ is H, C_1-6 alkyl or C_3-8 cycloalkyl, R⁵ is H, R⁶ is aminosulphonyl, R⁷ is H or a halogen atom, R⁸ is H, R⁹ is C_1-6 alkyl, C_1-6 alkoxy or a halogen atom, m, n, p and q are equal to 1, or pharmaceutically acceptable salts thereof. What is also presented is a pharmaceutical composition, use of the compound and a method of treatment.

EFFECT: disclosed compounds have inhibitory activity on the autotoxin and carbonic anhydrase II and can be used for treating or preventing ocular pathological conditions.

17 cl, 7 ex