AMIDE DERIVATIVES AS GRP119 AGONISTS Russian patent published in 2018 - IPC C07D401/12 C07D401/14 A61K31/454 A61K31/497 A61K31/506 A61P3/10 

FIELD: pharmacology.

SUBSTANCE: invention relates to an amide derivative of the following formula 1, its stereoisomers or its pharmaceutically acceptable salts of formula 1, wherein X₁, X₂, X₃, X₄, X₅, X₆, X₇ and X₈ each independently is C or N; R₁ is -F or -C_1-3-perfluorinated alkyl; R₂ and R₃ each is independently selected from the group consisting of halogen, -C_1-5-alkyl and C_3-6-cycloalkyl, wherein -C_1-5-alkyl and C_3-6cycloalkyl independently of one another may be unsubstituted or substituted by halogen, -CN, -OC_1-5-alkyl or-C_1-5-alkyl, or R₂ and R₃ together with the carbon atom to which they are attached, can form C_3-6-cycloalkyl, where C_3-6cycloalkyl may be unsubstituted or substituted by halogen, -OC_1-5-alkyl or -C_1-5-alkyl; R₄ and R₅ each independently is H, halogen or -C_1-5-alkyl; R₆ and R₇ each independently is H, halogen, -C_1-5-alkyl or -CN; R₈ means methyl; R₉ means H, halogen or OH; and m is 1 or 2. The invention also relates to individual compounds and to a pharmaceutical composition.

EFFECT: new compounds of formula 1 are obtained that have the properties of GPR119 agonists, which can be used in diabetes mellitus treatment.

7 cl, 15 tbl