FIELD: biotechnology.
SUBSTANCE: invention represents an immunogenic composition containing an isolated or recombinant polypeptide antigen of a non-typable strain H. influenzae NTHI1292 (NT067) and one or more pharmaceutically acceptable carriers, diluents and/or adjuvants, for use in a method of inducing a protective immune response to H. influenzae infection in a mammal, wherein said antigen NT067 is a polypeptide comprising the amino acid sequence SEQ ID NO: 5 or SEQ ID NO: 52. Invention also relates to a method for preventing or treating infections caused by a non-typable strain of H. influenzae, which comprises a step of administering to the mammal an effective amount of the above composition.
EFFECT: antigens and antigen compositions are disclosed.
18 cl, 5 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| ANTIGEN-BINDING MOLECULE CAPABLE OF MULTIPLE BINDING TO A VARIETY OF ANTIGEN MOLECULES | 2018 |
|
RU2757786C2 |
| ANTIGEN-BINDING MOLECULE INDUCING AN IMMUNE RESPONSE TO A TARGET ANTIGEN | 2012 |
|
RU2722829C2 |
| CHIMERIC ANTIGEN RECEPTOR | 2018 |
|
RU2770002C2 |
| MYCOBACTERIAL ANTIGEN COMPOSITION | 2015 |
|
RU2702194C2 |
| ANTIGEN-BINDING MOLECULE TO ACCELERATE ANTIGEN DISAPPEARANCE THROUGH FcγRIIB | 2013 |
|
RU2812226C1 |
| ANTIGEN-BINDING MOLECULE TO ACCELERATE ANTIGEN DISAPPEARANCE THROUGH FCΓRIIB | 2013 |
|
RU2736349C2 |
| ANTIBODY TO B7-H4, ITS ANTIGEN-BINDING FRAGMENT AND ITS PHARMACEUTICAL USE | 2019 |
|
RU2792748C2 |
| ANTIBODY TO TIGIT AND ITS USE | 2019 |
|
RU2786434C2 |
| IMMUNOACTIVATING ANTIGEN-BINDING MOLECULE | 2015 |
|
RU2722788C2 |
| CHIMERIC ANTIGEN RECEPTORS TARGETING HER2 | 2016 |
|
RU2753695C2 |
