METHOD FOR SYNTHESIS OF NOVEL CHIRAL LIGAND, METAL CHELATE, VARIOUS UNNATURAL AMINO ACIDS, MARAVIROC AND MAIN INTERMEDIATE COMPOUNDS THEREOF Russian patent published in 2020 - IPC C07D207/16 C07D409/12 C07D401/04 C07F15/04 C07C227/34 C07C229/34 

FIELD: chemistry.

SUBSTANCE: invention relates to a method of synthesis of a novel quaternary carbon chiral ligand. Method of synthesis includes a step for synthesis of compound of formula IV,

,

where n is integer from 1 to 4; R is selected from a group consisting of C1-C4-alkyl, C1-C4-halogenalkyl; R₁ is selected from a group consisting of C1-C4-alkyl, C1-C4-halogenalkyl and unsubstituted or substituted phenyl, where substituted phenyl means that phenyl has 1–5 substitutes, and each substitute is independently selected from a group consisting of halogen; R₂ is selected from a group consisting of H, halogen and C1-C4-alkyl; R₃ is selected from a group consisting of C1-C4-alkyl, unsubstituted or substituted phenyl and - (C1-C4 alkylene) - (unsubstituted or substituted phenyl), where substituted phenyl means that phenyl has 1–5 substitutes, and each substitute is independently selected from a group consisting of halogen, C1-C4-alkyl and C1-C4-halogenalkyl. Also disclosed are a method of producing an alpha-amino acid, an alpha-substituted beta-amino acid and a beta-substituted beta-amino acid, an intermediate compound Maraviroc, a chiral ligand having a structure of formula IV, a method for synthesis of an intermediate compound Maraviroc, method of synthesis of a non-natural amino acid, a method for synthesis of a basic intermediate compound of Maraviroc and a method for synthesis of Maraviroc.

EFFECT: invention enables to optimize the Maraviroc synthesis scheme and improve optical purity of the product.

9 cl, 124 ex