INHIBITORS OF LYSINE-SPECIFIC GINGIPAIN Russian patent published in 2020 - IPC C07C233/62 C07D277/28 C07D277/64 C07D277/24 C07D417/12 C07D409/12 C07D213/50 C07D213/53 A61K31/4402 A61K31/428 A61K31/426 A61P31/04 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a compound of formula I or a pharmaceutically acceptable salt thereof, wherein Z is halo-substituted phenoxymethylcarbonyl; A is -CH₂-; B and D are hydrogen; R¹ denotes hydrogen; R² is hydrogen and R³ is selected from a group consisting of cyclohexyl, cyclopentyl, morpholino, phenyl, piperidinyl, pyridinyl, tetrahydrofuranyl, tetrahydropyranyl, 1,2,3,4-tetrahydronaphthyl and thiazolyl, each of which is independently unsubstituted or independently substituted with 1–3 members selected from methyl, methoxy, trifluoromethyl, acetyl and -N₃; and R⁴ is hydrogen.

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EFFECT: compounds of formula I are intended for inhibiting lysine-specific gingipain Porphyromonas gingivalis.

8 cl, 10 dwg, 2 tbl, 37 ex