DERIVATIVES OF DOLASTATIN 10 AND AURISTATINS Russian patent published in 2018 - IPC C07K5/27 C07K7/02 A61K38/08 A61P35/00 

Abstract RU 2662951 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (I), wherein: - R1 is H or OH, - R2 is (C1-C6)alkyl, COOH, COOMe or a thiazolyl group, - R3 is H or (C1-C6)alkyl group, and - R4 is phenyl-(C1-C8)alkyl group substituted with one or more groups selected from groups OH and NR9R10, or to a pharmaceutically acceptable salt thereof, pharmaceutical compositions containing same, and methods for preparation thereof. (I)

EFFECT: compounds can be used to treat cancer or benign proliferative disorders.

12 cl, 64 ex

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RU 2 662 951 C2

Authors

Peres Mishel

Rilatt Ajan

Lamot Mari

Dates

2018-07-31Published

2014-04-25Filed