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2 729 937

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IPC

G09B23/28(2006-01-01)

A61F9/07(2006-01-01)

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Application

2019136663, 2019-11-15

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Start date

2019-11-15

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Actual filing date

2019-11-15

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Published

2020-08-13

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Inventor

Neroeva Nataliya VladimirovnaNeroev Vladimir VladimirovichKatargina Lyudmila AnatolevnaRyabina Marina VladimirovnaIlyukhin Pavel AndreevichKarmokova Asiyat GisovnaLosanova Oksana ArsenovnaMajbogin Artemij MikhajlovichLagarkova Mariya AndreevnaEremeev Artem ValerevichKharitonov Anatolij Evgenevich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Meditsinskij Issledovatelskij Tsentr Glaznykh Boleznej Imeni Gelmgoltsa" Ministerstva Zdravookhraneniya Rossijskoj Federatsii Gb Im. Gelmgoltsa" Minzdrava Rossii)Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Nauchno-Klinicheskij Tsentr Fiziko-Khimicheskoj Meditsiny Federalnogo Mediko-Biologicheskogo Agentstva" Fnkts Fkhm Fmba Rossii

METHOD OF SUBRETINAL TRANSPLANTATION OF RETINAL PIGMENT EPITHELIUM (RPE) CELLS DIFFERENTIATED FROM HUMAN INDUCED PLURIPOTENT STEM CELLS, WITH ATROPHY OF RETINAL PIGMENT EPITHELIUM IN EXPERIMENT Russian patent published in 2020 - IPC G09B23/28 A61F9/07 

Abstract RU 2729937 C1

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to ophthalmology and can be used for subretinal transplantation of retinal pigment epithelium (RPE) cells differentiated from human induced pluripotent stem cells (IPSC-RPE), for treating retinal diseases accompanying retinal pigment epithelium atrophy. Rabbits with atrophy of retinal pigment epithelium in subretinal space are introduced with suspension of induced pluripotent stem cells of retinal pigment epithelium (IPSC-RPE) in amount of 0.05 ml in amount of 50,000 cells. After the introduction of stem cells, the injection site is sealed with 2-3 drops of autologous plasma enriched with thrombocytes (PRP – Platelet-richplasma).

EFFECT: method enables increasing the functional retinal activity in the eyes with RPE atrophy with higher integration capacity and functioning of IPSC-RPE.

1 cl, 1 ex, 5 dwg

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RU 2 729 937 C1

Authors

Neroeva Nataliya Vladimirovna

Neroev Vladimir Vladimirovich

Katargina Lyudmila Anatolevna

Ryabina Marina Vladimirovna

Ilyukhin Pavel Andreevich

Karmokova Asiyat Gisovna

Losanova Oksana Arsenovna

Majbogin Artemij Mikhajlovich

Lagarkova Mariya Andreevna

Eremeev Artem Valerevich

Kharitonov Anatolij Evgenevich

Dates

2020-08-13—Published

2019-11-15—Filed

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