METHOD OF TRANSPLANTATION OF RETINAL PIGMENT EPITHELIUM (RPE) CELLS DIFFERENTIATED FROM INDUCED HUMAN PLURIPOTENT STEM CELLS, WITH RETINAL PIGMENT EPITHELIUM ATROPHY Russian patent published in 2020 - IPC A61F9/07 

Abstract RU 2730937 C1

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to ophthalmology, and can be used for transplantation of cells of retinal pigment epithelium differentiated from induced pluripotent stem, at retinal pigment epithelium (RPE) atrophy in experiment on rabbits. Induced retinal detachment according to the area of RP atrophy and through a linear section of retina in the area of detachment is introduced subretinal induced pluripotent stem cells (IPSC) RPE, fixed in form of monolayer on substrate with thickness of 50 mcm, obtained by electrospinning and consisting of 50 % of nanofibres of hydrophilic polyurethane and 50 % of gelatin.

EFFECT: method enables improving functional activity of the retina in eyes with RP atrophy, creating bases in the form of a substrate for providing adequate adhesion of RPE stem cells in a polarized monolayer, which will increase engraftment and functioning of IPSC-RPE.

1 cl, 1 ex, 4 dwg

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RU 2 730 937 C1

Authors

Neroeva Nataliya Vladimirovna

Neroev Vladimir Vladimirovich

Katargina Lyudmila Anatolevna

Ryabina Marina Vladimirovna

Ilyukhin Pavel Andreevich

Karmokova Asiyat Gisovna

Losanova Oksana Arsenovna

Majbogin Artemij Mikhajlovich

Lagarkova Mariya Andreevna

Eremeev Artem Valerevich

Laktionov Pavel Petrovich

Kharitonov Anatolij Evgenevich

Dates

2020-08-26Published

2019-11-01Filed