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2 830 558

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C1

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IPC

A61K38/13(2006-01-01)

A61K31/45(2006-01-01)

A61K31/56(2006-01-01)

A61P27/02(2006-01-01)

A61F9/07(2006-01-01)

(21) (22)

Application

2024109400, 2024-04-08

(24)

Start date

2024-04-08

(22)

Actual filing date

2024-04-08

(45)

Published

2024-11-21

(72)

Inventor

Neroeva Nataliya VladimirovnaBalatskaya Natalya VladimirovnaNeroev Vladimir VladimirovichKatargina Lyudmila AnatolevnaBrilliantova Angelina GrantovnaIzmajlova Natalya SergeevnaLagarkova Mariya Andreevna

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Meditsinskij Issledovatelskij Tsentr Glaznykh Boleznej Imeni Gelmgoltsa" Ministerstva Zdravookhraneniya Rossijskoj Federatsii Gb Im. Gelmgoltsa" Minzdrava Rossii)

METHOD FOR STUDYING BIOLOGICAL ACTION OF POTENTIAL BIOMEDICAL CELL PRODUCTS BASED ON HUMAN CELLS IN SUBRETINAL XENOGENEIC TRANSPLANTATION IN EXPERIMENT Russian patent published in 2024 - IPC A61K38/13 A61K31/45 A61K31/56 A61P27/02 A61F9/07 

Abstract RU 2830558 C1

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to ophthalmology. A rabbit with a model of retinal pigment epithelium atrophy immediately after transplantation undergoes a single intravitreal injection of 0.2 ml of the preparation Kenalog in concentration of 40 mg/ml. From the first postoperative day, Cyclosporine A solution is administered orally as a part of a food mixture in concentration of 100 mg/ml and in dose of 10 mg per 1 kg of body weight once a day for the entire period of the experiment.

EFFECT: invention enables to reproduce the state of immunological tolerance in experimental animals with an RPE atrophy model for studying the biological effects of potential biomedical cell products.

1 cl, 7 dwg, 2 ex

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RU 2 830 558 C1

Authors

Neroeva Nataliya Vladimirovna

Balatskaya Natalya Vladimirovna

Neroev Vladimir Vladimirovich

Katargina Lyudmila Anatolevna

Brilliantova Angelina Grantovna

Izmajlova Natalya Sergeevna

Lagarkova Mariya Andreevna

Dates

2024-11-21—Published

2024-04-08—Filed

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