DISPIROINDOLINONES BASED ON RHODANINES AS P53-MDM2 INHIBITORS OF PROTEIN-PROTEIN INTERACTION Russian patent published in 2020 - IPC C07D513/20 A61K31/429 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula 1, where R₁ is selected from group comprising 4-ethoxyphenyl, 4-chlorophenyl, 4-bromophenyl; R₂ is selected from a group comprising phenyl, 4-ethoxyphenyl, 2-chlorophenyl, 3-chlorophenyl, 4-chlorophenyl, 4-ethylphenyl, 3,4-dimethoxyphenyl, 4-methoxyphenyl, 4-fluorophenyl, 2-methylphenyl; R₃ is selected from a group comprising a chlorine, bromine or hydrogen atom; R₄ represents a hydrogen atom or propargyl HC≡C-CH₂-. Invention also relates to a method of producing compounds of formula 1, use as protein-protein interaction inhibitor MDM2/p53, pharmaceutical composition and a medicinal agent for treating oncological disease associated with protein-protein interaction MDM2/p53 and inhibition method.

EFFECT: technical result is compounds of formula 1 as inhibitors of protein-protein interaction MDM2/p53.

7 cl, 1 tbl, 33 ex