FIELD: chemistry.
SUBSTANCE: invention relates to 2',5'-diarylspiro[indole-3,3'-pyrrolidine]-2(1H)-ones of formula I, where R1 denotes a hydrogen atom, a methyl group or a halogen atom, R2 denotes phenyl, which may comprise from 0 to 3 halogen atoms, a tert-butyl groups or methoxy groups, or electron-enriched heteroaromatic substituent is furanyl, R3 represents phenyl, which may comprise from 0 to 1 halogen atoms, and a process for their preparation.
EFFECT: compounds of formula I possessing antitumoral activity.
6 cl, 1 tbl, 7 ex
| Title | Year | Author | Number |
|---|---|---|---|
| 4-SUBSTITUTED N-ARYL-1,8-NAPHTHALIMIDES, EXHIBITING PROPERTIES OF FLUORESCENT SENSORS ON METAL CATIONS AND METHODS FOR PRODUCTION THEREOF | 2012 |
|
RU2515195C1 |
| METHOD FOR CHROMAN-2-AMINES DERIVATIVES PRODUCTION | 2016 |
|
RU2652119C1 |
| CYTOTOXIC LINEAR HETEROCYCLIC DERIVATIVES OF ANTHRACENEDIONE HAVING IN SIDE CHAIN CYCLIC DIAMINES, ACTIVE TOWARDS TUMOUR CELLS WITH MULTIDRUG RESISTANCE | 2009 |
|
RU2412166C1 |
| N,N-BIS(2-(DIALKYLAMINO)ETHYL)CARBOXAMIDES AND THEIR DIHYDROCHLORIDES WITH ANTIARRHYTHMIC ACTIVITY AND PHARMACEUTICAL COMPOSITION BASED THEREON | 2017 |
|
RU2645080C1 |
| N-(2-(2-(DIALKYLAMINO)ETHOXY)ETHYL)CARBOXAMIDES AND HYDROCHLORIDES THEREOF, HAVING ANTIARRHYTHMIC ACTIVITY, AND PHARMACEUTICAL COMPOSITIONS BASED THEREON | 2019 |
|
RU2712638C1 |
| TRIPHENYLPHOSPHONIUM SALTS OF LUPANE TRITERPERNOIDS, METHOD FOR PRODUCING AND USING AS ANTICANCER AGENTS | 2012 |
|
RU2551647C2 |
| ENANTIOMERICALLY PURE BASIC ARYLCYCLOALKYLHYDROXYCARBOXYLIC ACID ESTERS, METHOD FOR THEIR PREPARING AND APPLYING IN MEDICINAL AGENTS | 1997 |
|
RU2238936C2 |
| FLUORINE-CONTAINING TEVINOL AND ORVINOL DERIVATIVES AND METHODS OF THEIR OBTAINING (VERSIONS) | 2012 |
|
RU2506265C1 |
| ADAMANTYL-CONTAINING DERIVATIVES OF 1,2,4-TRIAZOLE AND 1,3,4-THIADIAZOLE HAVING MONOTERPENOID FRAGMENTS USED AS INHIBITORS OF THE ENZYME TYROSYL-DNA PHOSPHODIESTERASE 1 | 2020 |
|
RU2761880C1 |
| HIGHLY ACTIVE METATHESIS CATALYSTS SELECTIVE FOR ROMP AND RCM REACTIONS | 2010 |
|
RU2546656C2 |
