VACCINE COMPOSITIONS CHARACTERIZED BY IMPROVED STABILITY AND IMMUNOGENICITY Russian patent published in 2020 - IPC A61K39/155 A61K9/00 

Abstract RU 2730625 C2

FIELD: biotechnology.

SUBSTANCE: described is a group of inventions comprising a vaccine composition for inducing a protective immune response to a virus and a method of preventing a viral infection involving administering a vaccine composition, where the virus is selected from a group consisting of respiratory syncytial virus (RSV), rabies virus, Ebola virus and influenza virus. In one version of the invention, the vaccine composition contains a nanoparticle containing a core which contains a non-ionic detergent, and a viral glycoprotein associated with the nucleus, wherein the viral glycoprotein is selected from a group consisting of F-glycoprotein RSV, Ebola virus glycoprotein, rabies virus G-protein, influenza virus haemagglutinin (HA) protein, influenza virus neuraminidase (NA) protein and combinations thereof.

EFFECT: invention extends the range of agents for inducing an immune response to a virus.

23 cl, 50 dwg, 1 tbl, 25 ex

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RU 2 730 625 C2

Authors

Smith Gale

Liu Ye

Tian Jing-Hui

Massare Michael

Boddapati Sarathi

Shane Erica

Oliver Cynthia

Glenn Gregory

Dates

2020-08-24Published

2016-09-06Filed