HEXOSE DERIVATIVES, PRODUCTION AND USE THEREOF Russian patent published in 2020 - IPC C07H9/06 C07H15/04 A61K47/26 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a compound, a pharmaceutically acceptable salt thereof, a based composition thereof and a method for use thereof in industry for stabilizing enzymes, where the compound is characterized by one of the formulas:

,

where R¹ is

R² is -OH or -N(H)C(=O)CH₃;

,

where R¹ is -OC(H)(X)(CH₂)_nC(=O)OH; R² is -OH or -N(H)C(=O)CH₃; X is -CH₃, -CH₂OH or CH₂C(=O)OH; n equals 0 or 1;

,

where R¹ is -OC(H)(X)(CH₂)_nC(=O)OH; R² is -OH or -N(H)C(=O)CH₃; and X is -H or CH₂C(=O)OH; n equals 0 or 1; R₁ is

in cases where the compound is

and R² is OH, X is H and n is 0, then said compound is

;

and when the compound is

and R² is OH, X is CH₂OH and n is 0, then the compound is

.

EFFECT: novel compounds and based compositions thereof, effective for stabilizing a polypeptide, an enzyme, an antibody, plasma protein, hormone, insulin, malate dehydrogenase, staphylococcus nuclease or lysozyme.

29 cl, 51 ex, 7 tbl, 11 dwg