FIELD: chemistry.
SUBSTANCE: invention relates to compounds of formulae (1), (2) or (3), or pharmaceutically acceptable salt thereof. Invention also relates to a pharmaceutical composition containing as an active ingredient a compound of formulae (1), (2) or (3), having inhibitory action on O-GlcNAcase, or a pharmaceutically acceptable salt thereof and pharmaceutically acceptable carrier. Compounds or pharmaceutically acceptable salt thereof are intended for treating Alzheimer's disease, Parkinson's disease or progressive supranuclear palsy (PSP) in a human patient in need thereof.
EFFECT: technical result is compounds which are selective inhibitors of glycosidase.
45 cl, 6 tbl, 33 ex
(1), (2),
(3).
Title | Year | Author | Number |
---|---|---|---|
SELECTIVE GLYCOSIDASE INHIBITORS AND USE THEREOF | 2011 |
|
RU2592285C2 |
PERMEABLE GLYCOSIDASE INHIBITORS AND USE THEREOF | 2013 |
|
RU2707292C2 |
SELECTIVE GLYCOSIDASE INHIBITORS AND THEIR APPLICATION | 2012 |
|
RU2625308C2 |
GLYCOSIDASE INHIBITORS AND THEIR APPLICATIONS | 2013 |
|
RU2672873C2 |
MACROCYCLIZATION REACTIONS AND INTERMEDIATE COMPOUNDS AND OTHER FRAGMENTS SUITABLE FOR PREPARING ANALOGUES OF HALICHONDRIN B | 2014 |
|
RU2710545C2 |
RMT5 INHIBITORS | 2019 |
|
RU2814198C2 |
AMIDES OF CONDENSED PIPERIDINE AS MODULATORS OF ION CHANNELS | 2014 |
|
RU2741810C2 |
PRINCE REACTION AND INTERMEDIATE PRODUCTS USED IN SYNTHESIS OF HALICHONDRIN MACROLIDES AND THEIR ANALOGUES | 2017 |
|
RU2777913C2 |
CONDENSED AMINOHYDROTHIAZINE DERIVATIVE | 2009 |
|
RU2476431C2 |
SUBSTITUTED PURINE AND 7-DEAZAPURINE COMPOUNDS | 2011 |
|
RU2606514C2 |
Authors
Dates
2017-01-31—Published
2011-12-21—Filed