FIELD: biotechnology.
SUBSTANCE: described is a group of inventions comprising a recombinant infectious herpes virus, a nucleic acid for producing said herpesvirus, nucleic acid for producing mature glycoprotein H (gH) of recombinant infectious herpes virus, a vector for producing recombinant infectious herpes virus, a cell for producing recombinant infectious herpesvirus, method for cell destruction using recombinant infectious herpesvirus and a method for cultivation of recombinant infectious herpesvirus in cells in vitro. In one embodiment, the herpes virus comprises a heterologous polypeptide ligand attached to the N-end of the glycoprotein H (gH), which lacks N-terminal region to amino acid at position 48 according to SEQ ID NO: 1.
EFFECT: invention widens the range for producing recombinant infectious herpes viruses.
15 cl, 9 dwg, 9 ex
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