SYNTHETIC GLUCOPYRANOSYL LIPOID ADJUVANTS Russian patent published in 2020 - IPC A61K31/7024 C07H11/04 A61P37/02 A61K31/7028 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to a method for treating an infection caused by Mycobacterium tuberculosis, comprising administering a composition comprising a GLA compound having the following structure (I):

(I)

or a pharmaceutically acceptable salt thereof, where L₁, L₂ , L₃, L₄, L₅ and L₆ are identical or different and independently represent -O- or -NH-; L₇, L₈, L₉ and L₁₀ are identical or different and independently absent or are -C (= O) -; Y₁ is -OP (O) (OH)₂; Y₂, Y₃ and Y₄ each represent -OH; R₁, R₃, R₅ and R₆ are identical or different and independently represent C_8-13-alkyl; and R₂ and R₄ are identical or different and independently represent C_6-11-alkyl.

EFFECT: novel effective method of treating tuberculosis by enhancing the immune response.

8 cl, 4 dwg, 45 ex