PYRIMIDINE COMPOUND Russian patent published in 2021 - IPC C07D239/49 C07D239/46 A61K31/506 A61K39/00 A61K39/39 A61P37/02 A61P37/04 

FIELD: pharmaceutics.

SUBSTANCE: invention relates to a heterocyclic compound of the formula (1) or its pharmaceutically acceptable salt, where X is methylene; R¹ and R² are independently a substituted or unsubstituted alkyl group containing from 1 to 6 carbon atoms, provided that, when the alkyl group is substituted, it is substituted with a hydroxy group; R³ is an alkyl group containing from 1 to 6 carbon atoms; R⁴ is a hydrogen atom, or an alkoxy group containing from 1 to 6 atoms carbon; Y¹ is a simple bond or -(CR⁹R¹⁰)_p-, where R⁹ and R¹⁰ are independently a hydrogen atom; Y² is a simple bond or -C(O)-; L is unsubstituted linear alkylene containing from 2 to 6 carbon atoms; R⁵ and R⁶ are independently a hydrogen atom or an unsubstituted alkyl group containing from 1 to 6 carbon atoms, or R⁵ and R⁶ are combined with a nitrogen atom, with which they are combined to form 6-element nitrogen-containing saturated heterocycle; m is equal to 1; p is an integer 1 and is a double bond. The invention also relates to a pharmaceutical composition based on the compound of the formula (1), the use of the compound of the formula (1) or a composition based on it, and a kit based on it.

EFFECT: new heterocyclic compounds are obtained that have properties of enhancing the antigen-specific immune response and improving the capability of an immune response.

17 cl, 5 dwg, 7 ex