FIELD: medicine; pharmaceuticals.
SUBSTANCE: invention relates to the polymorph of maleate (R)-methyl-2-(3-aminopiperidin-1-yl)-3-(2-cyanobenzyl)-4-carbonyl-3,4-dihydrothiophene [3,2-d] pyrimidin-6-carboxylic acid and methods for preparing it and a pharmaceutical composition. Polymorph is a crystal having high stability and low hygroscopicity, wherein the crystalline form is selected from crystalline form A, crystalline form B and crystalline form C.
EFFECT: crystalline form has hypoglycemic activity and can be used to produce a new drug for treating or preventing type II diabetes mellitus and/or complications of type II diabetes mellitus.
10 cl, 7 ex, 18 dwg
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