CRYSTALLINE FORM A OF COMPOUND AND METHOD FOR PRODUCTION THEREOF Russian patent published in 2019 - IPC C07D495/04 A61K31/519 A61P3/10 

FIELD: chemistry.

SUBSTANCE: invention relates to a crystalline form A of (R)-methyl-2-(3-aminopiperidin-1-yl)-3-(2-cyanobenzyl)-4-carbonyl-3,4-dihydrothiophene[3,2-d]pyrimidine-6-carboxylic acid of formula I, where the X-ray diffraction pattern (X-ray powder diffraction pattern) of crystalline form A includes the following characteristic absorption peaks, expressed by the distance between the crystal planes d: 8.87 ± 0.2 Å, 14.18 ± 0.2 Å, 20.67 ± 0.2 Å, 25.18 ± 0.2 Å, 28.61 ± 0.2 Å.

As well as to methods of producing and pharmaceutical composition of crystalline form A.

EFFECT: crystalline form A has strong hypoglycemic activity in vivo and is expected to be a novel pharmaceutically active ingredient for treating or preventing type II diabetes and/or complications of type II diabetes.

8 cl, 7 dwg, 6 ex