CRYSTALLINE OR AMORPHOUS FORM OF FXR AGONISTS BEING STEROID DERIVATIVES, THEIR PRODUCTION METHOD AND THEIR USE Russian patent published in 2023 - IPC C07J43/00 A61K31/58 A61P3/04 A61P3/06 A61P3/10 A61P9/10 A61P13/02 

Abstract RU 2800751 C2

FIELD: medicine.

SUBSTANCE: invention relates to crystalline form A of the compound of formula I, where its powder x-ray diffraction pattern contains diffraction peaks at 2Θ5.95°, 10.10°, 15.14°, 18.83°, 20.23° where error range 2Θ is ±0.2°, as well as to a method of its preparation and use for the treatment or prevention of a disease associated with the farnesoid X receptor.

EFFECT: obtaining a crystalline form of a new compound which is stable, pure and non-hygroscopic, and can be used in medicine for the treatment of diseases associated with the farnesoid X receptor (FXR), for example, such as non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), primary biliary cirrhosis (PBC), cholestatic hepatopathy, chronic liver disease, obesity, type 2 diabetes, etc.

7 cl, 12 dwg, 5 tbl, 3 ex

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RU 2 800 751 C2

Authors

Li, Syaolin

Syao, Khualin

Li, Pen

Khe, Khajin

Li, Vejdun

Dates

2023-07-27Published

2018-07-26Filed